Human Growth Hormone - Human Growth Hormone

Amazomone rHGH 1 x 18iu

AmazomoneTM is a kind of sterile, lyophilized formulation of Recombinant Human Growth Hormone (HGH) with 191 amino acids, derived from engineering E.coli, and it is identical to the natural growth hormone in amino acid sequence and three-dimension structure.

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AmazomoneTM is indicated for growth failure due to endogenous growth hormone deficiency (GHD) and Turner disease or Kidney failure. AmazomoneTM can be used to heal up the surgery wound or burned wound. It has perfect anti-ageing effects. Our manufacturing plants of AmazomoneTM are certified for GMP Standard by SFDA.

  * Adopting secretion engineering technique,identical to the natural growth hormone in amino acid sequence and three-dimension structure, exerts the same pharmacodynamics and pharmacokinetics of endogenous human growth hormone.
  * Higher bioactivity
  * Higher purity
  * Clinically safe, no significant side effects. Quick metabolized inside human body, without accumulation.
  * clinical data proved that this product has perfect effects in accelerating human growth, wounds healing and anti-ageing, while discarding the side effects of normal hormone products.

Human Growth Hormone

Growth hormone, also known as somatotropin , is a protein hormone of about 190 amino acids that is synthesized and secreted by cells called somatotrophs in the anterior pituitary. It is a major participant in control of several complex physiologic processes, including growth and metabolism. Read the 2003 American Association of Clinical Endocrinologist's Guidelines on HGH Treatment (PDF Format).

Physiologic Effects of Growth Hormone

A critical concept in understanding growth hormone activity is that it has two distinct types of effects:

Direct effects are the result of growth hormone binding its receptor on target cells. Fat cells (adipocytes), for example, have growth hormone receptors, and growth hormone stimulates them to break down triglyceride and suppresses their ability to take up and accumulate circulating lipids.

Indirect effects are mediated primarily by an insulin-like growth factor-1 (IGF-1), a hormone that is secreted from the liver and other tissues in response to growth hormone. A majority of the growth promoting effects of growth hormone is actually due to IGF-1 acting on its target cells.

Keeping this distinction in mind, we can discuss two major roles of growth hormone and its minion IGF-1 in physiology.

Effects on Growth

Growth is a very complex process, and requires the coordinated action of several hormones. The major role of growth hormone in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. IGF-1 stimulates proliferation of chondrocytes (cartilage cells), resulting in bone growth. Growth hormone does seem to have a direct effect on bone growth in stimulating differentiation of chondrocytes.

IGF-1 also appears to be the key player in muscle growth. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Metabolic Effects

Growth hormone has important effects on protein, lipid and carbohydrate metabolism. In some cases, a direct effect of growth hormone has been clearly demonstrated, in others, IGF-1 is thought to be the critical mediator, and some cases it appears that both direct and indirect effects are at play.

Protein metabolism: In general, growth hormone stimulates protein anabolism in many tissues. This effect reflects increased amino acid uptake, increased protein synthesis and decreased oxidation of proteins.

Fat metabolism: Growth hormone enhances the utilization of fat by stimulating triglyceride breakdown and oxidation in adipocytes.

Carbohydrate metabolism: Growth hormone is one of a battery of hormones that serves to maintain blood glucose within a normal range. Growth hormone is often said to have anti-insulin activity, because it suppresses the abilities of insulin to stimulate uptake of glucose in peripheral tissues and enhance glucose synthesis in the liver. Somewhat paradoxically, administration of growth hormone stimulates insulin secretion, leading to hyperinsulinemia.

Control of Growth Hormone Secretion

Production of growth hormone is modulated by many factors, including stress, exercise, nutrition, sleep and growth hormone itself. However, its primary controllers are two hypothalamic hormones and one from the stomach:

Growth hormone-releasing hormone (GHRH) is a peptide that stimulates both the synthesis and secretion of growth hormone.

Somatostatin (SS)is a peptide produced by several tissues in the body, including the hypothalamus. Somatostatin inhibits growth hormone release in response to GHRH and to other stimulatory factors such as low blood glucose concentration.

Ghrelin is a peptide hormone secreted from the stomach. Ghrelin binds to receptors on somatotrophs and potently stimulates secretion of growth hormone.

Growth hormone secretion is also part of a negative feedback loop involving IGF-1 . High blood levels of IGF-1 lead to decreased secretion of growth hormone not only by directly suppressing the somatotroph, but also by stimulating release of